CAS No. 14639-25-9

Batch: Purity:99.54
Check CoA
Chromium picolinate Chemical Structure
Chemical Structure
Check the Chromium picolinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 14639-25-9
Molecular Formula

C18H12CrN3O6
Molecular Weight (MW) 418.3
SMILES C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Cr+3]

Ordering Information

Biological Activity

Chromium picolinate is a coordination complex of chromium(III) and picolinic acid that acts as an enhancer of insulin signaling pathways. It promotes insulin sensitivity by increasing insulin receptor substrate-1 (IRS-1) association with phosphatidylinositol 3-kinase (PI3K) and enhancing downstream AKT phosphorylation. These cellular actions facilitate glucose transporter translocation, thereby stimulating glucose uptake and metabolic regulation in insulin-responsive tissues.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 5 mg/mL (11.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.