CAS No. 28319-77-9

Batch: Purity:98
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Choline Glycerophosphate Chemical Structure
Chemical Structure
Check the Choline Glycerophosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 28319-77-9
Molecular Formula

C8H20NO6P
Molecular Weight (MW) 257.22
SMILES C[N+](C)(C)CCOP(=O)([O-])OCC(CO)O

Biological Activity

Choline Glycerophosphate (glycerophosphorylcholine) is an endogenous choline derivative that serves as an essential precursor for acetylcholine synthesis and membrane phospholipid biosynthesis. It crosses the blood-brain barrier to increase cytosolic choline levels, thereby enhancing central cholinergic neurotransmission and acetylcholine release in brain tissues. Furthermore, glycerophosphorylcholine participates in lipid metabolism and helps maintain cellular membrane integrity in neuronal cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 51 mg/mL
Ethanol 51 mg/mL
DMSO 2 mg/mL (7.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lopez CM, et al. Pharmacol Biochem Behav. 1991;39(4):835-40.

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Note: Technical data last updated: Sep 1, 2026.