Home Metabolism PPAR agonist Chiglitazar (Carfloglitazar)

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Chiglitazar (Carfloglitazar) PPAR agonist

Chiglitazar (Carfloglitazar) is a potent dual agonist of PPARα and PPARγ with EC50 values of 1.2 μM and 0.08 μM, respectively, and also activates PPARδ with an EC50 of 1.7 μM. It effectively improves insulin resistance and corrects dyslipidemia in monosodium L-glutamate (MSG)-induced obese rats.

Chiglitazar (Carfloglitazar) PPAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 572.62

Purity & Quality Control

Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Mechanism of Action

In Vivo
In vivo

After insulin injection, plasma glucose levels in the MSG rats treated with Chiglitazar or rosiglitazone are significantly reduced compared with the control group treated with vehicle at all time points. Fasting PI levels are lower in animals treated with Chiglitazar and rosiglitazone than control. The ISIs of MSG obese rats treated with chiglitazar and rosiglitazone are significantly higher than control. Furthermore, Chiglitazar ameliorates the HOMA indices. For IPGTT, at the 30?min after glucose loading, the glucose values in the 5 and 10?mg?/kg Chiglitazar and rosiglitazone-treatment groups are significantly lower than those in the vehicle treatment group. The integrated for the glucose response during the IPGTT in the treatment groups are significantly less than those in the control groups.

References
  • https://pubmed.ncbi.nlm.nih.gov/16751799/
  • https://pubmed.ncbi.nlm.nih.gov/23150725/

Chemical Information

Molecular Weight 572.62 Formula

C36H29FN2O4
CAS No. 743438-45-1 SDF Download SDF
Smiles O=C(C1=CC=C(F)C=C1)C(C=CC=C2)=C2N[C@H](C(O)=O)CC(C=C3)=CC=C3OCCN4C5=CC=CC=C5C6=CC=CC=C46

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