CAS No. 138-60-3

Batch: Purity:98
Check CoA
Chelidamic acid hydrate Chemical Structure
Chemical Structure
Check the Chelidamic acid hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-oxo-1H-pyridine-2,6-dicarboxylic acid
CAS Number 138-60-3
Molecular Formula

C7H5NO5·xH2O
Molecular Weight (MW) 183.12
SMILES C1=C(NC(=CC1=O)C(=O)O)C(=O)O
InChIKey XTLJJHGQACAZMS-UHFFFAOYSA-N

Ordering Information

Biological Activity

Chelidamic acid hydrate is a heterocyclic dicarboxylic acid derivative and a potent inhibitor of glutamate decarboxylase. By inhibiting glutamate decarboxylase activity, it disrupts the enzymatic conversion of L-glutamate into gamma-aminobutyric acid (GABA), thereby suppressing GABA synthesis and modulating downstream neurotransmission pathways. Furthermore, chelidamic acid exhibits reported anti-inflammatory activity and skin-whitening effects, serving as a functional cosmetic intermediate.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (196.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.