CAS No. 2095616-82-1
Batch:
Purity:99.50
Chemical Structure
Check the
CH7057288
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-tert-butyl-2-[2-[8-(methanesulfonamido)-6,6-dimethyl-11-oxonaphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methylpyridine-4-carboxamide | |
|---|---|---|
| CAS Number | 2095616-82-1 | |
| Molecular Formula |
C32H31N3O5S |
|
| Molecular Weight (MW) | 569.67 | |
| SMILES | CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C)C(=O)NC(C)(C)C | |
| InChIKey | DCGOHGQJHJXBGW-UHFFFAOYSA-N |
CH7057288 is a potent and selective tropomyosin receptor kinase (TRK) inhibitor targeting TRKA, TRKB, and TRKC family receptors. By selectively inhibiting neurotrophic receptor tyrosine kinase activity, CH7057288 suppresses downstream oncogenic cascade signaling through the MAPK/ERK and AKT/mTOR pathways. This targeted blockade effectively inhibits cellular proliferation, survival, and colony formation while inducing apoptotic cell death in TRK-dependent cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(175.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.