CAS No. 2055918-71-1

Batch: Purity:99.70
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CH6953755 Chemical Structure
Chemical Structure
Check the CH6953755 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[5-amino-1-[6-(2,6-difluorophenoxy)-4-methyl-3-pyridinyl]pyrazole-4-carbonyl]-5-methyl-1H-indol-6-yl]methanesulfonamide
CAS Number 2055918-71-1
Molecular Formula

C26H22F2N6O4S
Molecular Weight (MW) 552.55
InChIKey YVXUHNOWRKWXSJ-UHFFFAOYSA-N

Biological Activity

CH6953755 is an orally active and selective small-molecule inhibitor of YES1 kinase (IC50 = 1.8 nM). Inhibition of YES1 kinase by CH6953755 disrupts downstream YAP1 transcriptional signaling by modulating YAP1 nuclear translocation and serine phosphorylation. This targeted pathway suppression effectively impairs cancer cell proliferation and drives robust antitumor efficacy across diverse YES1 gene-amplified tumor models both in vitro and in vivo. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hamanaka N, et al. Cancer Res. 2019;79(22):5734-5745.

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Note: Technical data last updated: Sep 1, 2026.