CAS No. 959763-06-5
Batch:
Purity:99.05
Chemical Structure
Check the
CH5138303
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[4-amino-6-(7-chloro-3-oxatricyclo[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaen-8-yl)-1,3,5-triazin-2-yl]sulfanyl]butanamide | |
|---|---|---|
| CAS Number | 959763-06-5 | |
| Molecular Formula |
C19 H18 Cl N5 O2 S |
|
| Molecular Weight (MW) | 415.9 | |
| SMILES | C1C2=C3C(=CC(=C(C3=CC=C2)C4=NC(=NC(=N4)SCCCC(=O)N)N)Cl)CO1 | |
| InChIKey | VIGHQZSTZWNWFA-UHFFFAOYSA-N |
CH5138303 is an orally available heat shock protein 90 (Hsp90) inhibitor. By binding to the Hsp90 molecular chaperone, it disrupts chaperone complex formation and destabilizes oncogenic client proteins. This targeted inhibition suppresses critical downstream signaling pathways, including AKT/mTOR and MAPK cascades, which ultimately inhibits cell proliferation and induces apoptotic cell death in cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.