CAS No. 1007207-67-1
Batch:
Purity:99.67
Chemical Structure
Check the
CH5132799
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine | |
|---|---|---|
| CAS Number | 1007207-67-1 | |
| Molecular Formula |
C15H19N7O3S |
|
| Molecular Weight (MW) | 377.42 | |
| SMILES | CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N | |
| InChIKey | JEGHXKRHKHPBJD-UHFFFAOYSA-N |
CH5132799 is a class I PI3K inhibitor targeting PI3Kα (IC50 0.014 μM), PI3Kγ (IC50 0.036 μM), PI3Kβ (IC50 0.12 μM), and PI3Kδ (IC50 0.5 μM). By suppressing the PI3K/AKT/mTOR signaling pathway, CH5132799 blocks downstream signaling cascades to inhibit cell proliferation. It demonstrates marked antitumor activity in cancer cell lines and tumor xenograft models harboring PIK3CA mutations. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(31.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.