CAS No. 874101-00-5
Batch:
Purity:99.48
Chemical Structure
Check the
RO4987655
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,4-difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5-[(3-oxooxazinan-2-yl)methyl]benzamide | |
|---|---|---|
| CAS Number | 874101-00-5 | |
| Molecular Formula |
C20H19F3IN3O5 |
|
| Molecular Weight (MW) | 565.28 | |
| InChIKey | FIMYFEGKMOCQKT-UHFFFAOYSA-N |
RO4987655 is a potent allosteric inhibitor of MEK that selectively targets the kinase within the MAPK/ERK cascade. By inhibiting MEK activity, the compound prevents downstream ERK phosphorylation and signaling, resulting in the downregulation of key cellular processes. Consequently, RO4987655 exhibits significant anti-proliferative activity and induces marked tumor growth inhibition across preclinical cancer models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.