CAS No. 164658-13-3
Batch:
Purity:99.85
Chemical Structure
Check the
CGP60474
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]-2-pyridinyl]amino]propan-1-ol | |
|---|---|---|
| CAS Number | 164658-13-3 | |
| Molecular Formula |
C18H18ClN5O |
|
| Molecular Weight (MW) | 355.82 | |
| SMILES | OCCCNC1=NC=CC(=C1)C2=NC(=NC=C2)NC3=CC=CC(=C3)Cl | |
| InChIKey | IYNDTACKOAXKBJ-UHFFFAOYSA-N |
CGP60474 is a potent ATP-competitive cyclin-dependent kinase (CDK) inhibitor targeting CDK1, CDK2, CDK4, CDK5, CDK7, and CDK9. By suppressing CDK signaling and cell cycle machinery, it halts cell cycle progression at the G1/S and G2/M transitions, thereby inhibiting cell proliferation and inducing apoptosis. Additionally, CGP60474 modulates inflammatory pathways to suppress proinflammatory mediator production, demonstrating potent anti-endotoxemic activity.[1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.