CAS No. 75450-34-9
Batch:
Purity:99.97
Chemical Structure
Check the
CGP-37157
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one | |
|---|---|---|
| CAS Number | 75450-34-9 | |
| Molecular Formula |
C15H11Cl2NOS |
|
| Molecular Weight (MW) | 324.22 | |
| SMILES | ClC1=CC2=C(NC(=O)CSC2C3=CC=CC=C3Cl)C=C1 | |
| InChIKey | KQEPIRKXSUIUTH-UHFFFAOYSA-N |
CGP-37157 functions as a selective inhibitor of the mitochondrial Na(+)-Ca2+ exchanger, effectively blocking calcium efflux from mitochondria at micromolar concentrations. Inhibition of this transporter modulates intracellular calcium homeostasis and prevents mitochondrial calcium overload, which subsequently influences downstream apoptotic pathways and cellular bioenergetics under pathological conditions. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.