CAS No. 905973-89-9
Batch:
Purity:99.95
Chemical Structure
Check the
CGK 733
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide | |
|---|---|---|
| CAS Number | 905973-89-9 | |
| Molecular Formula |
C23H18Cl3FN4O3S |
|
| Molecular Weight (MW) | 555.84 | |
| SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-] | |
| InChIKey | HLCDNLNLQNYZTK-UHFFFAOYSA-N |
CGK 733 is a potent inhibitor of ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases. By targeting ATM and ATR, CGK 733 disrupts DNA damage response pathways, impairing key downstream checkpoint signaling events. This inhibition compromises DNA repair mechanisms, leads to cell cycle checkpoint failure, and promotes apoptotic cell death in cancer cells, particularly when combined with DNA-damaging agents. [1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(179.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.