CAS No. 2704617-96-7
Batch:
Purity:98.7
Chemical Structure
Check the
CFT8634
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-3-[4-[4-[(4S)-1-[[2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-3-pyridinyl)phenyl]methyl]-3,3-difluoropiperidin-4-yl]piperazin-1-yl]-3-fluoroanilino]piperidine-2,6-dione | |
|---|---|---|
| CAS Number | 2704617-96-7 | |
| Molecular Formula |
C37H45F3N6O5 |
|
| Molecular Weight (MW) | 710.79 | |
| InChIKey | GNRGNRCQXHMQQV-ZQAZVOLISA-N |
CFT8634 is a potent heterobifunctional degrader targeting bromodomain-containing protein 9 (BRD9). It forms a ternary complex with BRD9 and cereblon Eligase, resulting in BRD9 ubiquitination and targeted proteasomal degradation. This depletion impairs non-canonical BAF (ncBAF) chromatin remodeling complex function, downregulating oncogenic transcriptional programs and inhibiting proliferation in SMARCB1-perturbed tumor cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(140.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.