CAS No. 1610759-22-2

Batch: Purity:99.22
Check CoA
Luvixasertib (CFI-402257) Chemical Structure
Chemical Structure
Check the Luvixasertib (CFI-402257) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-cyclopropyl-4-[7-[(3-hydroxy-3-methylcyclobutyl)methylamino]-5-pyridin-3-yloxypyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzamide
CAS Number 1610759-22-2
Molecular Formula

C28H30N6O3
Molecular Weight (MW) 498.58
InChIKey PMQUGSPFUBGJCZ-UHFFFAOYSA-N

Biological Activity

Luvixasertib (CFI-402257) is a threonine tyrosine kinase (TTK) inhibitor with an IC50 ofand a Ki of. By targeting TTK, it impairs spindle assembly checkpoint signaling and disrupts cell-cycle progression in cancer cells. This induces chromosome missegregation and apoptosis, while indirectly mobilizing immune cells within the tumor microenvironment.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (66.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.