CAS No. 2043659-93-2
Batch:
Purity:97.49
Chemical Structure
Check the
Cevidoplenib dimesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | cyclopropyl-[5-[[4-[4-[[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]methyl]-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]-1-methylindol-3-yl]methanone;methanesulfonic acid | |
|---|---|---|
| CAS Number | 2043659-93-2 | |
| Molecular Formula |
C25H27N7O3.2CH4O3S |
|
| Molecular Weight (MW) | 665.74 | |
| InChIKey | KGZICKLRNSIYNH-TXEPZDRESA-N |
Biological Activity
Cevidoplenib dimesylate is an orally bioavailable inhibitor of spleen tyrosine kinase (Syk) with anti-inflammatory and immunomodulatory activities. By inhibiting Syk, it suppresses downstream B-cell receptor and Fc receptor signaling pathways, thereby impairing autoantibody production and the activation of innate immune cells. In preclinical autoimmune models, cevidoplenib significantly reduces serum autoantibody titers, alleviates glomerulonephritis and proteinuria, and attenuates synovial tissue inflammation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(150.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 12 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.