CAS No. 2580154-02-3

Batch: Purity:99.35
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Certepetide (CEND-1; iRGD; LSTA1) Chemical Structure
Chemical Structure
Check the Certepetide (CEND-1; iRGD; LSTA1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2580154-02-3
Molecular Formula

C37H60N14O14S2
Molecular Weight (MW) 989.09

Ordering Information

Biological Activity

Certepetide (CEND-1; iRGD) is a tumor-penetrating cyclic peptide that selectively targets αV integrins on tumor endothelial cells. Upon proteolytic cleavage, it exposes a C-end Rule (CendR) motif that binds neuropilin-1 (NRP-1) to activate an endocytic transcytosis pathway. This process increases vascular and tissue permeability, significantly enhancing the intratumoral penetration and accumulation of co-administered anticancer therapeutics. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (101.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.