CAS No. 1798871-30-3
Batch:
Purity:99.17
Chemical Structure
Check the
Centrinone (LCR-263)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-fluoro-4-[(2-fluoro-3-nitrophenyl)methylsulfonyl]phenyl]sulfanyl-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidin-4-amine | |
|---|---|---|
| CAS Number | 1798871-30-3 | |
| Molecular Formula |
C26H25F2N7O6S2 |
|
| Molecular Weight (MW) | 633.65 | |
| SMILES | COC1=C(N=C(SC2=CC=C(C=C2F)[S](=O)(=O)CC3=CC=CC(=C3F)[N+]([O-])=O)N=C1NC4=N[NH]C(=C4)C)N5CCOCC5 | |
| InChIKey | HHJSKDRCUMVWKF-UHFFFAOYSA-N |
Centrinone (LCR-263) is a selective and reversible polo-like kinase 4 (PLK4) inhibitor with a Ki of. By inhibiting PLK4, Centrinone blocks centriole duplication, resulting in the continuous depletion of centrosomes in dividing cells. This disruption activates a p53-dependent cell cycle arrest in G1 phase or causes prolonged mitosis and genomic instability, effectively suppressing cell proliferation in various human cancer cell lines. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(157.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(78.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.