CAS No. 57470-78-7

Batch: Purity:99.41
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Celiprolol hydrochloride Chemical Structure
Chemical Structure
Check the Celiprolol hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 57470-78-7
Molecular Formula

C20H34ClN3O4
Molecular Weight (MW) 415.95
SMILES CCN(CC)C(=O)NC1=CC(=C(C=C1)OCC(CNC(C)(C)C)O)C(=O)C.Cl

Ordering Information

Biological Activity

Celiprolol hydrochloride is a selective β1-adrenoceptor antagonist that also exhibits intrinsic partial β2-adrenoceptor agonist activity. By selectively targeting and blocking β1-adrenoceptors, it attenuates adrenergic signaling pathways in cardiac tissues. Simultaneously, its partial agonist action at β2-adrenoceptors promotes peripheral vasodilation and bronchial smooth muscle relaxation. Through these dual mechanisms, it regulates vascular tone and cardiovascular responses via receptor-mediated signaling cascades.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 83 mg/mL
Ethanol 83 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.