CAS No. 64544-07-6
Batch:
Purity:99.65
Chemical Structure
Check the
Cefuroxime axetil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 64544-07-6 | |
|---|---|---|
| Molecular Formula |
C20H22N4O10S |
|
| Molecular Weight (MW) | 510.47 | |
| SMILES | CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N |
Biological Activity
Cefuroxime axetil is an orally active, second-generation cephalosporin prodrug that is hydrolyzed in vivo to release active cefuroxime. It exerts broad-spectrum antibacterial activity against various Gram-positive and Gram-negative organisms by targeting penicillin-binding proteins. Inhibition of these bacterial enzymes disrupts peptidoglycan cell wall biosynthesis, ultimately compromising structural integrity and inducing bactericidal cell lysis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.