CAS No. 73384-59-5
Batch:
Purity:97.79
Chemical Structure
Check the
Ceftriaxone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
|---|---|---|
| CAS Number | 73384-59-5 | |
| Molecular Formula |
C18H18N8O7S3 |
|
| Molecular Weight (MW) | 554.58 | |
| InChIKey | VAAUVRVFOQPIGI-SPQHTLEESA-N |
Ceftriaxone is a third-generation cephalosporin antibiotic that acts as a covalent inhibitor of glycogen synthase kinase-3β (GSK3β) with an IC50 of 0.78 μM after 60 minutes of preincubation. Covalent inhibition of GSK3β influences Wnt/β-catenin and NF-kB signaling pathways, thereby regulating downstream gene expression, inflammatory responses, and cell survival. In addition, ceftriaxone exhibits broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic bacterial species. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(180.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.