CAS No. 26973-24-0
Batch:
Purity:98
Chemical Structure
Check the
Ceftezole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 26973-24-0 | |
|---|---|---|
| Molecular Formula |
C13H12N8O4S3 |
|
| Molecular Weight (MW) | 440.48 | |
| SMILES | C1C(=C(N2C(S1)C(C2=O)NC(=O)CN3C=NN=N3)C(=O)O)CSC4=NN=CS4 |
Biological Activity
Ceftezole is a semi-synthetic first-generation cephalosporin antibiotic that possesses broad-spectrum antibacterial activity against various bacterial pathogens. It acts by binding to bacterial penicillin-binding proteins, thereby blocking transpeptidase-mediated peptidoglycan cross-linking required for cell wall assembly. Inhibition of this cell wall synthesis pathway weakens bacterial structural integrity, causing cell lysis and bacterial death in Gram-positive and Gram-negative organisms. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.