CAS No. 38821-53-3
Batch:
Purity:97.07
Chemical Structure
Check the
Cefradine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 38821-53-3 | |
|---|---|---|
| Molecular Formula |
C16H19N3O4S |
|
| Molecular Weight (MW) | 349.4 | |
| SMILES | CC1=C(N2C(C(C2=O)NC(=O)C(C3=CCC=CC3)N)SC1)C(=O)O |
Biological Activity
Cefradine is a semi-synthetic, first-generation cephalosporin antibiotic that targets bacterial penicillin-binding proteins (PBPs). By inhibiting PBPs, Cefradine interferes with the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall. This disruption weakens cell wall structural integrity, leading to osmotic instability, cell lysis, and bactericidal activity against a range of Gram-positive and Gram-negative bacteria.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 10 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.