CAS No. 1263369-28-3
Chemical Structure
Check the
CDK9-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-N-[5-chloro-4-[6-[(3-fluorophenyl)methylamino]-2-pyridinyl]-2-pyridinyl]cyclohexane-1,4-diamine | |
|---|---|---|
| CAS Number | 1263369-28-3 | |
| Molecular Formula |
C23H25ClFN5 |
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| Molecular Weight (MW) | 425.93 | |
| InChIKey | XKHXPTSUVPZYDW-UHFFFAOYSA-N |
CDK9-IN-2 is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9). CDK9 functions as the catalytic subunit of positive transcription elongation factor b (P-TEFb), which controls transcriptional elongation by phosphorylating RNA polymerase II. Inhibition of CDK9 suppresses the expression of anti-apoptotic factors, leading to antiproliferative effects and apoptosis across various cancer cell lines. [1]
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Note: Technical data last updated: Sep 1, 2026.