CAS No. 1163719-56-9
Batch:
Purity:99.89
Chemical Structure
Check the
CCT196969
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(3-tert-butyl-1-phenylpyrazol-5-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea | |
|---|---|---|
| CAS Number | 1163719-56-9 | |
| Molecular Formula |
C27H24FN7O3 |
|
| Molecular Weight (MW) | 513.52 | |
| SMILES | CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C(=NC=C3)NC(=O)C=N4)F)C5=CC=CC=C5 | |
| InChIKey | KYYKGSDLXXKQCR-UHFFFAOYSA-N |
CCT196969 is an orally bioavailable pan-RAF inhibitor with anti-SRC activity, which also inhibits LCK and p38 MAPKs. By dual targeting of RAF and SRC family kinases, it effectively blocks the MAPK signaling pathway without driving paradoxical activation. This concurrent inhibition suppresses downstream pathway signaling, impairs cell proliferation, and overcomes resistance to standard RAF and MEK inhibitors. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.