CAS No. 324759-76-4

Batch: Purity:99.74
Check CoA
CCT020312 Chemical Structure
Chemical Structure
Check the CCT020312 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-bromo-3-[3-(4-bromophenyl)-2-[3-(diethylamino)propanoyl]-3,4-dihydropyrazol-5-yl]-4-phenyl-1H-quinolin-2-one
CAS Number 324759-76-4
Molecular Formula

C31H30Br2N4O2
Molecular Weight (MW) 650.40
SMILES CCN(CC)CCC(=O)N1N=C(CC1C2=CC=C(Br)C=C2)C3=C(C4=CC=CC=C4)C5=C(NC3=O)C=CC(=C5)Br
InChIKey OAXDKXMGESZLKV-UHFFFAOYSA-N

Ordering Information

Biological Activity

CCT020312 is a selective protein kinase RNA-like endoplasmic reticulum kinase (PERK/EIF2AK3) activator. Selective PERK activation induces phosphorylation of eukaryotic initiation factor 2α (eIF2α), leading to activation of EIF2A-mediated translational control and G1/S cell cycle checkpoint arrest. Downstream, CCT020312 suppresses cancer cell proliferation and sensitizes tumor cells to chemotherapy-associated stresses elicited by taxanes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (153.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.