CAS No. 1813527-81-9
Batch:
Purity:99.27
Chemical Structure
Check the
CCG215022
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[4-fluoro-3-(pyridin-2-ylmethylcarbamoyl)phenyl]-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 1813527-81-9 | |
| Molecular Formula |
C26H22FN7O3
|
|
| Molecular Weight (MW) | 499.50 | |
| SMILES | CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=CC=CC=N3)C(=O)NC4=CC5=C(C=C4)NN=C5 | |
| InChIKey | BLMBNKDQXGINRE-UHFFFAOYSA-N |
Biological Activity
CCG215022 is a pan-G protein-coupled receptor kinase (GRK) inhibitor that acts against GRK1, GRK2, and GRK5. By selectively blocking GRK catalytic activity, CCG215022 prevents agonist-induced phosphorylation and subsequent desensitization of G protein-coupled receptors (GPCRs). This inhibition impairs β-arrestin recruitment and receptor endocytosis, thereby modulating downstream GPCR signaling cascades and cellular physiological responses.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(200.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.