CAS No. 1887069-10-4

Batch: Purity:99.00
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Gamcemetinib (CC-99677) Chemical Structure
Chemical Structure
Check the Gamcemetinib (CC-99677) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (15R)-5-[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one
CAS Number 1887069-10-4
Molecular Formula

C22H20ClN5O3S
Molecular Weight (MW) 469.95
InChIKey PYOQIOLRFIRRSO-LLVKDONJSA-N

Biological Activity

Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2) within the p38/MK2 pathway. Covalent binding to MK2 suppresses the phosphorylation of heat shock protein 27 (HSP27) and tristetraprolin (TTP). Inhibition of TTP phosphorylation destabilizes inflammatory cytokine transcripts, resulting in reduced downstream production of tumor necrosis factor (TNF), interleukin-6 (IL-6), and IL-17. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Malona J, et al. Transl Res. 2022;249:49-73.

[2] Gaur R, et al. Arthritis Res Ther. 2022;24(1):199.

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Note: Technical data last updated: Sep 1, 2026.