CAS No. 1706738-98-8

Batch: Purity:99.89
Check CoA
Trotabresib (CC-90010) Chemical Structure
Chemical Structure
Check the Trotabresib (CC-90010) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one
CAS Number 1706738-98-8
Molecular Formula

C21H21NO4S
Molecular Weight (MW) 383.46
SMILES CN1C=C(C2=CC=CC=C2C1=O)C3=C(OCC4CC4)C=CC(=C3)[S](C)(=O)=O
InChIKey UWZAJPITKGWMFJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Trotabresib (CC-90010) is a reversible, orally active, and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. By targeting BET proteins, it disrupts the binding of bromodomain modules to acetylated lysine residues on histones, suppressing chromatin remodeling and downstream oncogenic transcription. This pathway inhibition reduces MYC gene expression and impairs tumor cell growth, supporting its potential utility in preclinical models of advanced solid tumors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (200.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.