CAS No. 1621999-82-3
Batch:
Purity:99.69
Chemical Structure
Check the
CC-90003
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[[2-[(2-methoxy-5-methyl-4-pyridinyl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]-5-methylphenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1621999-82-3 | |
| Molecular Formula |
C22H21F3N6O2 |
|
| Molecular Weight (MW) | 458.44 | |
| SMILES | CC1=CC(=C(C=C1)NC2=NC(=NC=C2C(F)(F)F)NC3=CC(=NC=C3C)OC)NC(=O)C=C | |
| InChIKey | ILUKRINUNLAVMH-UHFFFAOYSA-N |
CC-90003 is a potent, irreversible inhibitor targeting ERK1 and ERK2 with high kinase selectivity. By disrupting ERK1/2 kinase activity within the MAPK/ERK signaling pathway, it prevents downstream phosphorylation of nuclear and cytoplasmic substrates. This inhibition blocks cellular proliferation, suppresses downstream oncogenic gene expression, and induces apoptosis in tumor cells driven by hyperactive MAPK pathway signaling.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.