CAS No. 1618658-88-0

Batch: Purity:99.74
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CC-671 Chemical Structure
Chemical Structure
Check the CC-671 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamide
CAS Number 1618658-88-0
Molecular Formula

C28H28N6O4
Molecular Weight (MW) 512.56
SMILES CNC(=O)C1=CC(=C(NC2=NC3=C(C(=N2)OC4CCCC4)C(=C[NH]3)C5=CC6=C(C=C5)N=C(C)O6)C=C1)OC
InChIKey CWJLAVRXVFHDSJ-UHFFFAOYSA-N

Biological Activity

CC-671 is a potent dual inhibitor targeting TTK (monopolar spindle 1) and CDC-like kinase 2 (CLK2). Inhibition of TTK impairs the spindle assembly checkpoint and causes premature mitotic exit, resulting in severe chromosome missegregation. Concurrently, targeting CLK2 disrupts RNA splicing and cell growth pathways, ultimately leading to cell cycle arrest, mitotic catastrophe, and apoptosis in tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (195.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] ArakiK, et al. Cancer Research. 2013;73(24_Supplement):P6-06-45-P6-06-45.

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Note: Technical data last updated: Sep 1, 2026.