CAS No. 1015474-32-4

Batch: Purity:99.87
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Avadomide (CC-122) Chemical Structure
Chemical Structure
Check the Avadomide (CC-122) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
CAS Number 1015474-32-4
Molecular Formula

C14H14N4O3
Molecular Weight (MW) 286.29
SMILES CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N
InChIKey RSNPAKAFCAAMBH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Avadomide (CC-122) is a cereblon (CRBN) modulator that targets the substrate receptor of the CRL4-CRBN E3 ubiquitin ligase complex. Binding to CRBN promotes the ubiquitination and proteasomal degradation of Ikaros (IKZF1) and Aiolos (IKZF3), leading to downregulation of IRF4 and MYC. This pleiotropic mechanism drives cell cycle arrest, apoptosis, and immunomodulatory responses, demonstrating significant antitumor activity in diffuse large B-cell lymphoma (DLBCL) models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.