CAS No. 2416095-06-0
Batch:
Purity:99.03
Chemical Structure
Check the
CBR-470-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3S,4R)-4-(4-chlorophenyl)sulfonyl-N-(2-methylpropyl)-1,1-dioxothiolan-3-amine | |
|---|---|---|
| CAS Number | 2416095-06-0 | |
| Molecular Formula |
C14H20ClNO4S2 |
|
| Molecular Weight (MW) | 365.90 | |
| InChIKey | NFEQFEDSWINARK-KBPBESRZSA-N |
Biological Activity
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) and a non-covalent activator of Nrf2. Pharmacological inhibition of PGK1 leads to the accumulation of methylglyoxal, which modifies Keap1 to trigger Keap1-Nrf2 dissociation and downstream gene expression. Through activation of the Keap1-Nrf2 cascade, CBR-470-1 attenuates oxidative stress and protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.