CAS No. 1863952-15-1
Batch:
Purity:98.13
Chemical Structure
Check the
CB-5339
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide | |
|---|---|---|
| CAS Number | 1863952-15-1 | |
| Molecular Formula |
C24H24N6O |
|
| Molecular Weight (MW) | 412.49 | |
| InChIKey | XDHFSLWWYBVSLN-UHFFFAOYSA-N |
Biological Activity
CB-5339 is a potent inhibitor of p97, also known as valosin-containing protein (VCP). Selective inhibition of p97/VCP disrupts cellular proteostasis and endoplasmic reticulum-associated degradation, leading to severe accumulation of polyubiquitinated protein substrates. Consequently, this target blockade induces proteotoxic stress, activates the unfolded protein response, and promotes apoptotic cell death while suppressing cancer cell proliferation. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(242.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.