CAS No. 218457-67-1

Batch: Purity:99.77
Check CoA
Limantrafin (CB-103) Chemical Structure
Chemical Structure
Check the Limantrafin (CB-103) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(4-tert-butylphenoxy)pyridin-3-amine
CAS Number 218457-67-1
Molecular Formula

C15H18N2O
Molecular Weight (MW) 242.32
SMILES CC(C)(C)C1=CC=C(OC2=CC=C(N)C=N2)C=C1
InChIKey WHIWGRCYMQLLAO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Limantrafin (CB-103) is an orally active inhibitor of the Notch transcription activation complex. By blocking Notch-mediated transcriptional activation, it disrupts downstream Notch signaling cascades critical for oncogenic cell proliferation and survival. Consequently, CB-103 induces Notch loss-of-function phenotypes in animal models and demonstrates robust antitumor efficacy by suppressing the growth of human breast cancer and leukemia xenografts. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (198.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 48 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.