CAS No. 1233706-88-1
Batch:
Purity:99.93
Chemical Structure
Check the
CAY10650
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-(2-methylpropanoyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid | |
|---|---|---|
| CAS Number | 1233706-88-1 | |
| Molecular Formula |
C28H25NO6 |
|
| Molecular Weight (MW) | 471.50 | |
| InChIKey | HTOJZPHWNDZOPQ-UHFFFAOYSA-N |
Biological Activity
CAY10650 is a potent inhibitor of cytosolic phospholipase A2α (cPLA2α). By selectively suppressing cPLA2α enzymatic activity, CAY10650 blocks the receptor-stimulated release of arachidonic acid and subsequent eicosanoid mediator production within inflammatory signaling pathways. Consequently, this targeted inhibition reduces downstream pro-inflammatory lipid mediator synthesis and exerts marked anti-inflammatory effects in murine contact dermatitis models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.