CAS No. 1045792-66-2
Batch:
Purity:99.85
Chemical Structure
Check the
CAY10603 (BML-281)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate | |
|---|---|---|
| CAS Number | 1045792-66-2 | |
| Molecular Formula |
C22H30N4O6 |
|
| Molecular Weight (MW) | 446.5 | |
| SMILES | CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO | |
| InChIKey | WWGBHDIHIVGYLZ-UHFFFAOYSA-N |
CAY10603 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2 pM and greater than 200-fold selectivity over other HDAC isoforms. By inhibiting HDAC6, CAY10603 increases the acetylation of α-tubulin without significantly affecting histone acetylation. This selective inhibition disrupts microtubule-dependent cellular processes, suppressing cell motility and inhibiting tumor cell proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.