CAS No. 1218777-13-9
Batch:
Purity:99.88
Chemical Structure
Check the
CAY10505
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione | |
|---|---|---|
| CAS Number | 1218777-13-9 | |
| Molecular Formula |
C14H8FNO3S |
|
| Molecular Weight (MW) | 289.28 | |
| SMILES | C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)NC(=O)S3)F | |
| InChIKey | UFBTYTGRUBUUIL-KPKJPENVSA-N |
CAY10505 is a potent and selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitor that targets the PI3K/AKT signaling pathway. By inhibiting PI3Kγ, CAY10505 suppresses downstream substrate phosphorylation of AKT in macrophages and reduces immune cell activation. In animal models, administration of this compound significantly decreases neutrophil recruitment, demonstrating its efficacy in modulating inflammatory responses and immune cell trafficking. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.