CAS No. 298186-80-8
Batch:
Purity:97
Chemical Structure
Check the
CAY10444
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 298186-80-8 | |
|---|---|---|
| Molecular Formula |
C15H29NO2S |
|
| Molecular Weight (MW) | 287.46 | |
| SMILES | CCCCCCCCCCCC1NC(CS1)C(O)=O |
CAY10444 (BML-241) is a synthetic thiazolidine carboxylic acid antagonist targeting the sphingosine-1-phosphate 3 (S1P3) receptor. Antagonism of the S1P3 signaling pathway by CAYinhibits ligand-stimulated intracellular calcium mobilization in receptor-expressing cellular models. In addition, CAYsuppresses intracellular calcium elevations driven by purinergic P2 receptors and alpha-1A adrenoceptors, leading to attenuated alpha-1 adrenoceptor-mediated arterial contraction without altering cyclic AMP accumulation. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(48.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
29 mg/mL
(100.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.