CAS No. 1567335-29-8

Batch: Purity:99.62
Check CoA
Cav 2.2 blocker 1 Chemical Structure
Chemical Structure
Check the Cav 2.2 blocker 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole
CAS Number 1567335-29-8
Molecular Formula

C25H29ClN2O2
Molecular Weight (MW) 424.96
SMILES COC1=CC=CC=C1[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C4CC(C)(C)OC(C)(C)C4
InChIKey LDURKOGJFOYENC-UHFFFAOYSA-N

Biological Activity

Cav 2.2 blocker 1 is a potent inhibitor of N-type voltage-gated calcium channels (Cav2.2) evaluated for the management of chronic and neuropathic pain. By selectively blocking Cav2.2 channels, this compound inhibits calcium influx into presynaptic nociceptive neurons, thereby suppressing the release of pro-nociceptive neurotransmitters within the spinal cord dorsal horn. This inhibition disrupts pain signaling pathways and attenuates pain phenotypes in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 15 mg/mL
DMSO 12 mg/mL (28.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] McGivern JG. Drug Discov Today. 2006;11(5-6):245-53.

Jump to

Note: Technical data last updated: Sep 1, 2026.