CAS No. 429676-93-7
Batch:
Purity:99.04
Chemical Structure
Check the
Cathepsin G Inhibitor I
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid | |
|---|---|---|
| CAS Number | 429676-93-7 | |
| Molecular Formula |
C36H33N2O6P |
|
| Molecular Weight (MW) | 620.63 | |
| InChIKey | GNOZQRKYZJSIPZ-UHFFFAOYSA-N |
Cathepsin G Inhibitor I is a potent, reversible, and competitive inhibitor of cathepsin G. By targeted inhibition of cathepsin G proteolytic activity, this compound disrupts antigen processing and MHC class II presentation pathways, thereby attenuating downstream T cell receptor signaling and modulating adaptive immune and T cell responses in situ and in vivo. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(80.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.