CAS No. 4168-17-6

Batch: Purity:99.95
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Catharanthine hemitartrate Chemical Structure
Chemical Structure
Check the Catharanthine hemitartrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R)-2,3-dihydroxybutanedioic acid;bis(methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate)
CAS Number 4168-17-6
Molecular Formula

C46H54N4O10
Molecular Weight (MW) 822.94
InChIKey OXIDCVCPXUNSCI-DWGLLIDUSA-N

Ordering Information

Biological Activity

Catharanthine hemitartrate is an indole alkaloid serving as a primary precursor for the synthesis of antitumor bisindole alkaloids, such as vinblastine and vincristine. The downstream bisindole derivatives selectively bind to tubulin to disrupt microtubule assembly during mitosis. This inhibition prevents proper mitotic spindle formation, leading to cell cycle arrest at the M phase and subsequently inducing apoptotic cell death across multiple cancer cell lines.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (115.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.