CAS No. 179463-17-3
Batch:
Purity:99.98
Chemical Structure
Check the
Caspofungin (MK-0991) Acetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | acetic acid;N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide | |
|---|---|---|
| CAS Number | 179463-17-3 | |
| Molecular Formula |
C52H88N10O15.2C2H4O2 |
|
| Molecular Weight (MW) | 1213.42 | |
| SMILES | CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O)C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O | |
| InChIKey | OGUJBRYAAJYXQP-LLXMLGLCSA-N |
Biological Activity
Caspofungin Acetate (MK-0991) is an echinocandin lipopeptide antifungal agent that functions as a potent β-1,3-glucan synthase inhibitor. By selectively inhibiting the synthesis of 1,3-β-D-glucan, an essential structural component of the fungal cell wall, it disrupts cell wall integrity and leads to severe osmotic instability, cell lysis, and cell death in Candida and Aspergillus species.
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(82.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(82.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(82.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(82.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(82.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Jump to
- Caspofungin (MK-0991) Acetate Clinical Trials
- Caspofungin (MK-0991) Acetate Solubility in DMSO
- Caspofungin (MK-0991) Acetate Storage
- Caspofungin (MK-0991) Acetate Stability
- Caspofungin (MK-0991) Acetate Molecular Weight
- Caspofungin (MK-0991) Acetate SMILES
- Caspofungin (MK-0991) Acetate Chemical Structure (2D and 3D)
- Caspofungin (MK-0991) Acetate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.