CAS No. 87-44-5
Batch:
Purity:
Chemical Structure
Check the
β-Caryophyllene
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 87-44-5 | |
|---|---|---|
| Molecular Formula |
C15H24 |
|
| Molecular Weight (MW) | 204.35 | |
| SMILES | CC1=CCCC(=C)C2CC(C2CC1)(C)C |
Biological Activity
β-Caryophyllene is a natural bicyclic sesquiterpene that acts as a selective cannabinoid receptor type 2 (CB2) agonist (Ki = 155 nM). Activation of CB2 receptors by β-caryophyllene modulates neuroinflammatory signaling pathways, inhibiting lipopolysaccharide-induced pro-inflammatory cytokine expression, including TNF-α and IL-1β. These cellular anti-inflammatory responses mediate protective biological phenotypes in preclinical models of inflammation and pain. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.