CAS No. 64464-07-9

Batch: Purity:98
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Carvedilol EP IMpurity E Chemical Structure
Chemical Structure
Check the Carvedilol EP IMpurity E product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(2-methoxyphenoxy)ethanamine;hydrochloride
CAS Number 64464-07-9
Molecular Formula

C9H14ClNO2
Molecular Weight (MW) 203.67
SMILES COC1=CC=CC=C1OCCN.Cl
InChIKey KNWPXZOMSZABHD-UHFFFAOYSA-N

Biological Activity

Carvedilol is a nonselective beta-adrenergic receptor antagonist and alpha-1 adrenergic receptor blocker. By simultaneously inhibiting beta-1, beta-2, and alpha-1 adrenergic receptors, it modulates GPCR signaling pathways, reduces sympathetic nervous system activation, and inhibits vascular smooth muscle contraction. These combined actions lead to suppressed cardiac adrenergic stimulation and decreased peripheral vascular resistance, serving as a key reference compound in cardiovascular signaling research. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 41 mg/mL (201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ruffolo RR Jr, et al. Eur J Clin Pharmacol. 1990;38 Suppl 2:S82-8.

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Note: Technical data last updated: Sep 1, 2026.