CAS No. 5957-80-2
Batch:
Purity:99.63
Chemical Structure
Check the
Carnosol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one | |
|---|---|---|
| CAS Number | 5957-80-2 | |
| Molecular Formula |
C20H26O4 |
|
| Molecular Weight (MW) | 330.42 | |
| InChIKey | XUSYGBPHQBWGAD-PJSUUKDQSA-N |
Biological Activity
Carnosol is a naturally occurring phenolic diterpene exhibiting potent anti-oxidant, anti-inflammatory, and anti-cancer activities. It targets multiple cellular signaling networks, prominently inhibiting NF-kB activation and disrupting the AKT/mTOR pathway. Through these molecular mechanisms, carnosol downregulates pro-inflammatory mediator expression, suppresses tumor cell proliferation, and triggers apoptotic cell death across diverse cancer cell types. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.