CAS No. 154-93-8
Batch:
Purity:
Chemical Structure
Check the
Carmustine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1,3-bis(2-chloroethyl)-1-nitrosourea | |
|---|---|---|
| CAS Number | 154-93-8 | |
| Molecular Formula |
C5H9Cl2N3O2 |
|
| Molecular Weight (MW) | 214.05 | |
| SMILES | C(CCl)NC(=O)N(CCCl)N=O | |
| InChIKey | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
Carmustine is a cell-cycle phase-nonspecific nitrosourea alkylating agent. It alkylates nucleic acids and forms DNA interstrand cross-links, which effectively block both DNA replication and RNA transcription processes. Consequently, this targeted genomic disruption activates downstream DNA damage signaling pathways, leading to cell cycle arrest, inhibition of cellular proliferation, and induction of apoptotic cell death in cancer cells.
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(186.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
80 mg/mL
(373.74 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.