CAS No. 839712-12-8
Batch:
Purity:99.20
Chemical Structure
Check the
Cariprazine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 839712-12-8 | |
|---|---|---|
| Molecular Formula |
C21H32Cl2N4O |
|
| Molecular Weight (MW) | 427.41 |
Cariprazine is a dopamine receptor partial agonist displaying high affinity for dopamine D3 (pKi 10.07), D2L (pKi 9.16), and D2S receptors (pKi 9.31). It also binds serotonin receptors, acting as an antagonist at 5-HT2B (pKi 9.24), 5-HT1A (pKi 8.59), 5-HT2A (pKi 7.73), and 5-HT2C receptors (pKi 6.87). Modulation of these GPCR signaling pathways regulates central dopaminergic and serotonergic neurotransmission. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 6 mg/mL |
| DMSO |
3 mg/mL
(7.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.