CAS No. 1083076-69-0

Batch: Purity:99.65
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Cariprazine hydrochloride Chemical Structure
Chemical Structure
Check the Cariprazine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea;hydrochloride
CAS Number 1083076-69-0
Molecular Formula

C21H32Cl2N4O.HCl
Molecular Weight (MW) 463.87
InChIKey GPPJWWMREQHLQT-UHFFFAOYSA-N

Biological Activity

Cariprazine hydrochloride is a selective partial agonist of dopamine D3 receptors (Ki =, dopamine D2 receptors (Ki =, and serotonin 5-HT1A receptors (Ki =. Preferentially targeting D3 receptors, it modulates dopaminergic neurotransmission and downstream G protein-coupled receptor signaling pathways. In cellular and animal models, cariprazine regulates dopamine-mediated intracellular signaling events to produce potent antipsychotic-like and pro-cognitive behavioral responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 12 mg/mL (25.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kiss B, et al. J Pharmacol Exp Ther. 2010;333(1):328-40.

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Note: Technical data last updated: Sep 1, 2026.