CAS No. 1188-38-1
Batch:
Purity:99.57
Chemical Structure
Check the
Carglumic Acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1188-38-1 | |
|---|---|---|
| Molecular Formula |
C6H10N2O5 |
|
| Molecular Weight (MW) | 190.15 | |
| SMILES | C(CC(=O)O)C(C(=O)O)NC(=O)N |
Carglumic acid is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator. By mimicking NAG, carglumic acid allosterically activates CPS1, the initial and rate-limiting enzyme in the urea cycle. Activation of CPS1 promotes the conversion of ammonia into carbamoyl phosphate within the mitochondrial matrix, stimulating hepatic ureagenesis and facilitating ammonia clearance. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
38 mg/mL
(199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.