Carboxine SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Carboxine
CAS Number: 5234-68-4
PubChem CID: 21307
Molecular formula: C12H13NO2S
Molecular weight: 235.30 g/mol
IUPAC name: 6-methyl-N-phenyl-2,3-dihydro-1,4-oxathiine-5-carboxamide

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting unless directed by medical personnel. Seek medical attention.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Combustible. Heating may produce toxic fumes.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 203 °C

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Carboxin is resistant to mild oxidative and hydrolytic conditions. Alkaline hydrolysis yields the more toxic aniline. If reuse is not possible, incineration appears to be the method of choice for disposal. Recommendable method: Incineration. Not recommendable method: Alkaline hydrolysis.
Avoid contact with skin or clothing. Wash hands and face thoroughly with soap and water after use and before eating or smoking.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

7.1 Precautions for safe handling
Store in cool, dry area out of reach of children and animals.

7.2 Conditions for safe storage, including any incompatibilities
Store in cool, dry area out of reach of children and animals.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Carboxin appears as off-white crystals. Systemic fungicide and seed protectant.
b) Odor: No data available
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 91.5 to 92.5 °C and 98 to 101 °C, reflecting two crystalline structures which revert to one in solution.
f) Initial boiling point and boiling range: No data available
g) Flash point: 203 °C
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.00000018 [mmHg]
l) Vapor density: No data available
m) Relative density: 1.7 g/mL
n) Water solubility: 221.2 g/L in acetone, 89.33 g/L in methanol, 107.7 g/L in ethyl acetate, all at 20 °C.
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 2.1
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 63.6 Ų
Complexity: 295

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
No indication of carcinogenicity to humans (not listed by IARC).
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LD50 Anas platyrhynchos (Mallard duck, 14 day old) oral 6094 mg/kg/14 days
LC50 Anas platyrhynchos (Mallard duck, 5 day old) dietary >4110 ppm/8 days
LC50 Colinus virginianus (Northern bobwhite, juvenile) dietary >1000 ppm/8 days
LC50 Colinus virginianus (Northern bobwhite, 5 day old) dietary >5620 ppm/8 days
For more Ecotoxicity Values (Complete) data for CARBOXIN (26 total), please visit the HSDB record page.
/BIRDS and MAMMALS/ Following chronic exposure, mallard ducks (Anas platyrhynchos) exhibited reductions in the number of eggs laid, viable embryos, live 3-week embryos, normal hatchlings and 14-day survivors at 700 mg/kg/day.
/AQUATIC SPECIES/ /In/ two freshwater fish toxicity studies... Rainbow trout exposed to the four highest concentration levels (0.93, 1.5, 2.4, and 4.1 mg/L) demonstrated partial to complete loss of equilibrium, lethargy, darkened pigmentation and swimming on the surface. ...Bluegill sunfish exposed to the three highest concentrations, i.e., 2.7, 4.3, and 7.5 mg/L, also demonstrated partial to complete loss of equilibrium, lethargy, darkened pigmentation and swimming on the surface.
6.30e+03
8.20e+04
1.90e+03
5.00e+00
1.00e+00
1.00e-01
Volatile
Mutagen
1
0.1
1.90e+04
2.50e+05
5.70e+03
5.00e+00
1.00e-01
Volatile
Mutagen
1
0.1
Carboxin's production may result in its release to the environment through various waste streams; it's use as a fungicide for commercial seed treatment and on-farm seed treatment will result in its direct release to the environ

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): 2.1
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Not available in public databases.

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- EFSA Legal Basis: Commission Regulation (EC) No 33/2008
- Status Regulation (EC): 2011/52/EU, Reg. (EU) 2022/801, Reg. (EU) No 2018/1266, Reg. (EU) No 2019/324, Reg. (EU) No 540/2011
- Federal Drinking Water Guidelines: EPA 700 ug/L
- FIFRA Requirements: The Agency has completed its assessment of the dietary, occupational, residential, and ecological risk associated with the use of pesticide products containing the active ingredient carboxin. Based on a review of these data and on public comments on the Agency's assessments for the active ingredient

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.